San Francisco closed the 2025 preseason with a 30-23 win over Los Angeles, leaning on depth players as starters rested. Terique Owens delivered the standout performance with the top receiving grade, while Luke Farrell, Austen Pleasants, Connor Colby and Isaiah Prince supplied solid showings on the offensive front. Trevis Gipson anchored the D-line, with Nick Martin, Jordan Elliott, Siran Neal and Bruce Hector generating pressure and solid coverage. The night highlighted the 49ers’ reserve group as a blueprint for Week 1 depth.

Defensive grades and solid run/pass blocking marks suggested the 49ers can lean on a productive second unit as they tighten up the line and secondary rotations. The uneven start gave way to momentum on several drives, pointing to potential fantasy value for late-round picks and dynasty stashes who may emerge when regular-season snaps increase.

Isaiah Prince left San Francisco's preseason finale with a left‑leg injury, casting doubt on the 49ers' early depth at offensive tackle as rosters tighten. With Prince potentially sidelined, Austen Pleasants, Spencer Burford, and Nick Zakelj figure to absorb extra work and shape the Week 1 line, which in turn could impact run blocks and pass protection for the backfield.

Burford’s versatility, Zakelj’s length, and Pleasants’ depth role become fantasy-relevant if Prince misses time, since any extended absence could shift linemen roles and influence SF’s early-season efficiency in both the run game and the pass game. Managers should watch Prince’s timeline and any IR chatter as cuts loom.